We recommend minocycline if doxycycline is not tolerated, however it has a less favorable risk–benefit profile for treating acne compared with doxycycline. Like doxycycline, minocycline can cause gastrointestinal upset, benign intracranial hypertension and tooth discoloration. However, a recent meta-analysis showed no evidence that minocycline has a more prolonged effect or is more effective in acne resistant to other therapies and minocycline is associated with more severe adverse effects such as irreversible hyper pigmentation. Long-term treatment with minocycline can result in severe autoimmune liver damage and lupus erythematosus. More Information
Only a generation ago, it was thought that eating too many sweet or greasy foods caused acne; now doctors know much more about why breakouts happen and how to treat them. This section addresses common questions about acne.